KMID : 1038520220440010099
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Epidemiology and Health 2022 Volume.44 No. 1 p.99 ~ p.99
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Aspergillus sensitization associated with current asthma in children in the United States: an analysis of data from the 2005-2006 NHANES
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Hui-Ju Wen
Shu-Li Wang Cho Ju-Yeon Yue Leon Guo
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Abstract
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OBJECTIVES : This study investigated the association between allergen sensitization and current asthma in children in the United States using data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES).
METHODS : Children who participated in the 2005?2006 NHANES, aged 6 years to 19 years, were included in this study. A structured questionnaire was used to assess asthma status (without asthma, asthma in remission, or current asthma). Nineteen specific immunoglobulin E (sIgE) levels were measured using the Pharmacia Diagnostics ImmunoCAP 1000 System (Kalamazoo, MI, USA). A machine-learning method was applied to select important sIgEs related to childhood asthma. Multivariate regression analysis was used to test this hypothesis.
RESULTS : In total, 2,875 children were recruited. The prevalence of ever having asthma and current asthma was 16.5% and 5.6%, respectively. Six sIgE levels were found to contribute to asthma using bootstrap forest selection. After adjusting for the child¡¯s sex, age, and family income, children with double the sIgE levels of Dermatophagoides farinae, dogs, and Aspergillus were more likely to have current asthma than children without asthma (odds ratio [95% confident interval]: 1.11 [1.04 to 1.19], 1.30 [1.16 to 1.46], and 1.55 [1.39 to 1.72], respectively).
CONCLUSIONS : Our findings suggest that allergen sensitization, especially to Aspergillus, is associated with current asthma in children. Strategies to reduce sensitization may help prevent and manage asthma.
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KEYWORD
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IgE, Asthma, Children, Aspergillus
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